Ketone bodies are produced during pathological (e.g. untreated diabetes) or paraphysiological (starvation or prolonged exercise) states as an alternative metabolic fuel for muscles, heart and brain. Ketogenic diets, which are characterized by high fatty acid intake with concomitant low glucose consumption, are characterized with decreased NRLP3-inflammation, although their effect on the adipose tissue and its inflammatory features are widely unknown. In this paper, Dr Goldberg and colleagues demonstrated that ketogenic diet expands, in the adipose tissue, metabolically protective γδ T cells that restrain inflammation. On the other hand, long-term ad libitum KD feeding in mice causes obesity, impairs metabolic health and depletes the adipose-resident γδ T cells. In addition, mice lacking γδ T cells have impaired glucose homeostasis.
Source: Nature MetabolismLeave a reply