May 24, 2019 Last Updated 10:12 AM, May 22, 2019
Alessandro Leuti

Alessandro Leuti

Neural stem cells (NSC) are emerging as a very promising new therapeutic tools in neurodegenerative diseases by virtue of their immuno-modulatory abilities; however the cellular and molecular mechanism that are behind their properties have not been fully elucidated yet. In this paper, published on Cell Stem Cell by Luca Perruzzotti-Jametti and colleagues, demonstrated that NSCs might reduce neuroinflammation by reducing succinate, which acts as an immunometabolite that is produced by pro-inflammatory myeolid phagocytes, during immune response, by triggering a plethora of inflammatory stimuli.

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Spinal cord injury (SCI) is a devastating condition for which, to date, no effective clinical intervention has been found. Mesenchymal stem cells (MSCs) are emerging as possible cell-based therapy for many brain-related pathologies - including SCI - although the cellular and molecular mechanisms behind their effect are still quite unclear. In this paper, published on Scientific Reports, Katherine A. Ruppert and colleagues tried to administer MSC-derived endovescicles, which are thought to deliver paracrine regenerative factors, to rats undergoing spinal cord contusion.

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Senior european corrispondent Alyson Abbot summarizes the difficult situation of italian scientific and academic environment in the final weeks before elections.

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Microbiota has been recently emerging as an unexpectedly important partner in immune homeostasis and its disfunctions have been correlated to virtually every immunopathological condition.

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BRAYN Locandinadef02


The 1st Annual Scientific Meeting of the Italian Young Neuroscientists, BraYn (Brainstorming Research Assembly for Young Neuroscientists), which will be held in Genoa, Italy, during the 29th and 30th of June 2018, is inspired and organized by researchers under the age of 40 from different backgrounds and with different scientific approaches. The meeting aims establish connections between the future protagonists of Italian neuroscience.

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Registered area

Thanks to the support of
merck serono biogen sanofi

Conferences & Courses

17° Corso CRNI Viva la differenza: sesso e neuroimmunologia

March 7-10, 2018 
Bergamo - Bergamo Science Center


Encefaliti Autoimmuni e Malattie Demielinizzanti Atipiche

16 febbraio 2018
Aula Magna Giorgio De Sandre


JNIInternational Brain Research Organization
Bringing Neuroscience to the World
JNIJournal of Neuroimmunology
Studies on all branches of neurosciences covering both research and clinical problems of neuroscientific interest.

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