DEADLINE FOR REGISTRATION: June 30th
Under the patronage of AINI
The European Research Council recently published its annual review regarding funded projects that ended in mid-2015, and declared that around four out of five financed studies resulted in a major scientific advances and, among these, one out of five consisted in a fundamental breakthrough; these studies are already having considerable economic and social impact.
"Results that hold only for a particular mouse in a particular lab in a particular experiment are arguably not science.", says Philip Stark, statistic professor at Berkeley, as he addresses the problem of data replicability.
Francisco J. Quintana, which we had the plasure to listen in the last AINI congress in Trieste, published this astounding paper on Nature on the role played by the metabolites produced by the commensal flora on microglial cells, and the way they respectively control inflammation by modulating astrocyte functions.
"Vaccination has successfully reduced the burden of infectious diseases worldwide, but stagnating immunization coverage and lack of effective vaccines for many endemic and newly emerging pathogens pose a threat to sustainable global health."
"When John Harley lost a friend to lupus while in medical school, he vowed to get to the bottom of the disease, a chronic autoimmune disorder that causes fatigue, joint pain, skin rashes, and sometimes death. Now, some 40 years later, Harley says he’s found a “smoking gun.” The Epstein-Barr virus (EBV), which infects some 90% of Americans, may cause changes in gene expression that dramatically increase a person’s chance of getting lupus and six other autoimmune disorders, a new study by Harley and colleagues shows."
Thinking that immune memory is an exclusive feature of adaptive immunity is a common mistake, and recent evidences strongly indicates that the innate branch of our immune system is just as able to react adaptively to repeated stimuli, displaying a de facto innate immune memory. The molecular mechanism behind the ability of innate immune cells to be "trained" to act differentially to occasional or sustained stimuli resides in epigenetic modifications that are induced by imprinting signals that alter subsequent immune responses. Since innate immune cells are pivotal in inflammatory homeostasis in periphery as well as in the central nervous system (CNS) where they are involved in the modulation of neuronal functions, Ann-Christin Weldeln and colleagues, addressed an important question: is innate immune memory is involved in neuropathological alterations?