Aug 16, 2018 Last Updated 12:13 PM, Aug 1, 2018
AINI - Alessandro Leuti
Alessandro Leuti

Alessandro Leuti

Interleukin-2 (IL-2) is one of the most important cytokines of adaptive immunity. It was first identified as a principal autocrine mitogenic factor for T cells, as well as being the first product of recombinand DNA technology to be used as immuno-boosting treatment for human experimentation in pathologies in which immune modulation was a promising therapeutic strategy (e.g. cancer or AIDS). However, its role in adaptive immune response, as it was later discovered, goes well beyond that of a "mere" aspecific growth factor for T cells. Quite soon, in fact, researcers had to deal with the baffling evidence that patients with autoimmune disease displayed low production of IL-2, while mouse models with compromised IL-2 signal axis developed autoimmune conditions, a puzzle that was clarified only when Tregs were discovered.  

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The contact between T cell receptors (TCR), expressed by CD4 T lymphocytes, and the MHC on the surface of antigen presenting cells is crucial in leading the differentiation of naive T cells into effector cells that are required in the adaptive response against microbes. On the other hand, long-lasting immunity is guaranteed, in the aftermath of the fight against invading organisms, by memory T cells that emerge from a small population of effector T cells that survives the initial clonal expansion. 

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L'Associazione Italiana di Neuroimmunologia ha concesso il proprio patrocinio per le attività della Scuola quadriennale di Specializzazione post-laurea in Medicina e Chirurgia e in Psicologia dal titolo “Scuola di specializzazione in psicoterapia e neuroscienze orientata allo studio e al trattamento dei disturbi mentali e del comportamento nelle malattie neurologiche (PSICOMED)

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L'Associazione Italiana di Neuroimmunologia ha concesso il proprio patrocinio per le attività della Scuola quadriennale di Specializzazione post-laurea in Medicina e Chirurgia e in Psicologia dal titolo “Scuola di specializzazione in psicoterapia e neuroscienze orientata allo studio e al trattamento dei disturbi mentali e del comportamento nelle malattie neurologiche (PSICOMED)”.

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B cells play a role in most autoimmune conditions mostly due faulty immune tolerance, both central and peripheral, that should instead be meant to keep autoreactive cells at bay. In multiple sclerosis (MS) B cell aggregates located in the meninges and spinal cord seem to be an important factor that contributes to the compartmentalized CNS inflammation that is typical of this disease. Despite our incomplete knowledge of the cellular and molecular mechanisms underlying MS pathogenesis, great advances have been made in this field by research.

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Joseph Park and colleagues realized a novel 3D cellular model which allows to study the interactions and neuroinflammatory cues that occurbetween neurons, astrocytes and microglia in the inflammed human brain during Alzheimer's disease. 

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In this paper, published on Nature Communications by Simon Faissner and colleagues, the authors screened a group of 1040 compounds from the NINDS database in order to find a potential therapeutic compound for progressive multiple sclerosis, a diagnosis for which most of clinical trials have failed so far.

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Conferences & Courses

17° Corso CRNI Viva la differenza: sesso e neuroimmunologia

March 7-10, 2018 
Bergamo - Bergamo Science Center

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Encefaliti Autoimmuni e Malattie Demielinizzanti Atipiche

16 febbraio 2018
Aula Magna Giorgio De Sandre
POLICLINICO UNIVERSITARIO G.B. ROSSI - Verona

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JNIInternational Brain Research Organization
Bringing Neuroscience to the World
JNIJournal of Neuroimmunology
Studies on all branches of neurosciences covering both research and clinical problems of neuroscientific interest.

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