Apr 24, 2019 Last Updated 11:27 AM, Mar 29, 2019

Second patient free of HIV after stem-cell therapy

Published in Head news
Read 108 times
Rate this item
(0 votes)

Just a few days ago, the Cambridge team led by Ravindra Gupta announced that they had been able to eliminate HIV virus in a patient that had received a bone marrow transplant from a donor that carried two mutated copies of CCR5 -a mutation that occurs in around 1% of european descent- that confers HIV immunity to the host. The treated patient stopped taking antiretroviral drugs in the past 18 months after the transplant and, quite importantly, represents the second case of succesful HIV-treating transplant in recent years, the first having been reported in 2009. Interestingly, the idea behind a stem cell-based treatment came, for both patients, from the necessity of a bone marrow transplant as a treatment for a blood cancer that did not respond to chemotherapy; however, rather than chosing any compatible donor, Dr. Gupta opted for a patient with a double mutation for CCR5.

 

Even though all results point to a very promising perspective, at least in terms of the patient quality of life (after all, treatment of the first patient is still demonstrating its efficacy ten years later), there is still no way to formally talk about a cure -says Dr Gupta- until the absence of virus in the patient's blood will be demonstrated for longer time. Furthermore, this last transplant was achieved with a less aggressive cancer-treating regimen in respect with the one of 2009, suggesting that powerful chemotherapy might not be necessary for its efficacy. On the other hand, some have pointed out that this kind of treatment might not be suitable for people who don't have blood cancer, as bone marrow transplant is a rather serious procedure that would not be advisable for all HIV patients, especially for those with a good clinical phenotype.

Source: Nature

Original paper

Last modified on Tuesday, 12 March 2019 12:46
Login to post comments

Registered area

Thanks to the support of
merck serono biogen sanofi

Conferences & Courses

17° Corso CRNI Viva la differenza: sesso e neuroimmunologia

March 7-10, 2018 
Bergamo - Bergamo Science Center

READ MORE

Encefaliti Autoimmuni e Malattie Demielinizzanti Atipiche

16 febbraio 2018
Aula Magna Giorgio De Sandre
POLICLINICO UNIVERSITARIO G.B. ROSSI - Verona

READ MORE

JNIInternational Brain Research Organization
Bringing Neuroscience to the World
JNIJournal of Neuroimmunology
Studies on all branches of neurosciences covering both research and clinical problems of neuroscientific interest.

This website or its third party tools use cookies, which are necessary to its functioning and required to achieve the purposes illustrated in the cookie policy. If you want to know more or withdraw your consent to all or some of the cookies, please refer to the cookie policy. By closing this banner, scrolling this page, clicking a link or continuing to browse otherwise, you agree to the use of cookies. To find out more about the cookies we use and how to delete them, see our Cookie Policy