Aug 15, 2018 Last Updated 12:13 PM, Aug 1, 2018

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Head, Neuroimmunology Unit
Unità di Neuroimmunologia
Ospedale San Raffaele, Divisione di Neuroscienze, INSpe (Ist. Neurologia Sperimentale)


Collaboratori
Luca Muzio, Ricercatore
Marco Bacigaluppi, Post-Doc
Gianluca Breschi, Post-Doc
Erica Butti, Post-Doc
Melania Cusimano, Post-Doc
Simona Eleuteri, Post-Doc
Linda Ottoboni, Post-Doc
Andrea Bergamaschi, Tecnico di Laboratorio
Elena Brambilla, Tecnico di Laboratorio
Francesca Ruffini, Tecnico di Laboratorio
Donatella De Feo, Dottoranda
Hélène Descamps, Dottoranda
Amir Malvandi, Dottorando
Chiara Rossi, Dottoranda
Arianna Merlini, Specializzanda
Giorgia Gullotta, Borsista


Via Olgettina, 58 - V° Piano Palazzo San Gabriele 1
20132 Milano - Italia
Tel. +39 02 264 349 58
Fax +39 02 264 348 55
This email address is being protected from spambots. You need JavaScript enabled to view it.
www.hsr.it/ricerca/divisioni-centri-istituti-e-programmi-di-ricerca/istituto-di-neurologia-sperimentale-inspe/gianvito-martino/


Keywords su ambiti di competenza
Sclerosi, cellule staminali neurali, sistema nervoso centrale, microglia, infiammazione, encefalite autoimmune sperimentale, cellule staminali pluripotenti, ischemia cerebrale, neuroprotezione, modello di trauma del midollo spinale.


Tecniche utilizzate
Colture cellulari, rt-PCR, microcopia confocale, istologia, patch clamp, microdissezione, analisi di espressione genica, encefalite autoimmune sperimentale, ischemia cerebrale sperimentale, modello di trauma del midollo spinale, modelli transgenici.


Pubblicazioni
PLUCHINO S, QUATTRINI A, BRAMBILLA E, GRITTI A, SALANI G, DINA G, GALLI R, BERGAMI A, FURLAN R, DELCARRO U, AMADIO S, COMI G, VESCOVI AL, MARTINO G. Injection of adult neurospheres induce clinical recovery in a chronic model of multiple sclerosis. Nature 2003;422:688-694.

FURLAN R, BERGAMI A, CANTARELLA D, BRAMBILLA E, TANIGUCHI M, DELLABONA P, CASORATI G, MARTINO G. Activation of invariant NKT cells by a-GalCer administration protects mice from MOG35-55-induced EAE: a critical role for administration route and IFNg. Eur. J. Immunol. 2003:33:1830-1838.

LAMPASONA V, FRANCIOTTA DM, FURLAN R, ZANABONI S, FAZIO R, BONIFACIO E, COMI G, MARTINO G. Similar frequency of anti-MOG IgG and IgM in MS patients and healthy subjects. Neurology 2004;62:2092-2094.

PLUCHINO S, ZANOTTI L, ROSSI B, BRAMBILLA E, OTTOBONI L, SALANI G, MARTINELLO M, CATTALINI A, BERGAMI A, FURLAN R, COMI G, CONSTANTIN G, MARTINO G. Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism. Nature 2005;436:266-271.

MARTINO G, PLUCHINO S. The therapeutic potential of neural stem cells. Nat. Rev. Neurosci. 2006;7:395-406.

FURLAN R, BERGAMI A, BRAMBILLA E, BUTTI E, DE SIMONI MG, CAMPAGNOLI M, MARCONI P, COMI G, MARTINO G. HSV-1-mediated IL-1 receptor antagonist gene therapy ameliorates MOG35-55 induced experimental autoimmune encephalomyelitis in C57BL/6 mice. Gene Ther. 2007;14:93-98 (Epub ahead of print, August 24, 2006)

PLUCHINO S, MUZIO L, IMITOLA J, DELEIDI M, ALFARO-CERVELLO C, SALANI G, PORCHERI C, BRAMBILLA E, BERGAMASCHI A, GARCIA-VERDUGO JM, COMI G, KHOURY SJ*, MARTINO G*. Chronic inflammation induces a non cell-autonomous dysfunction of the endogenous brain stem cell compartment. (*equally contributed) Brain 2008;131: 2564-2578 [Epub ahead of print on Aug 30, 2008].

CENTONE D*, MUZIO L*, ROSSI S, CAVASINNI F, DE CHIARA V, BERGAMI A, MUSELLA A, MARCELLO D’AMELIO M, CAVALLUCCI V, MARTORANA A, BERGAMASCHI A, CONCIONI MT, DIAMANTINI A, BUTTI E, COMI G, BERNARDI G, CECCONI F, BATTISTINI L, FURLAN R, MARTINO G. Inflammation triggers synaptic alteration and degeneration in experimental autoimmune encephalomyelitis. J. Neurosci. 2009;29:3442-3452 (*equally contributed)

PLUCHINO S, ZANOTTI L, BRAMBILLA E, ROVERE-QUERINI P, CAPOBIANCO A, ALFARO-CERVELLO C, SALANI G, BORSELLINO G, BATTISTINI L, PONZONI M, DOGLIONI C, GARCIA-VERDUGO JM, COMI G, MANFREDI AA, MARTINO G. Multipotent neural stem/precursor cells protects from central nervous system autoimmunity by restraining dendritic cell function. PLoS One 2009;4:e5959 [Epub ahead of print on Jun 19, 2009]

PLUCHINO S*, GRITTI A*, BLAZER E, AMADIO S, BRAMBILLA E, BORSELLINO G, COSSETTI C, DEL CARRO U, COMI G, ‘T HART B, VESCOVI A, MARTINO G. Human neural stem cells ameliorate autoimmune encephalomyelitis in non human primates. Ann Neurol. 2009;66:343-354 (*equally contributed)

MARTINO G, FRANKLIN RJ, VAN EVERCOOREN AB, KERR DA, the Stem Cells in Multiple Sclerosis (STEMS) Consensus Group. Stem cell transplantation in multiple sclerosis: current status and future prospects. Nat Rev Neurol, 2010;6:247–255 [Epub ahead of print on Apr 20, 2010].

CENTONZE D, MUZIO L, ROSSI S, FURLAN R, BERNARDI G, MARTINO G. The link among inflammation, synaptic transmission and neurodegeneration in multiple sclerosis. Cell Death Differ. 2010;17:1083-1091 [Epub ahead of print on Nov 20, 2009].

MARTINO G, PLUCHINO S, BONFANTI L, SCHWARTZ M. Brain regeneration in physiology and pathology: the immune signature driving therapeutic plasticity of neural stem cells. Physiol. Rev. 2011;91:1281-1304.

DEFEO D, MERLINI A, LATERZA C, MARTINO G. Neural stem cell transplantation in CNS disorder: from cell replacement to neuroprotection. Curr. Opin. Neurol. 2012;25:322–333.

KOKAIA Z*, MARTINO G*, SCHWARTZ M*, LINDVALL O. Cross-talk between neural stem cells and immune cells: the key to better brain repair? Nat. Neurosci. 2012;15:1078-1087. (*equally contributed)

BUTTI E*, BACIGALUPPI M*, ROSSI S, CAMBIAGHI M, BARI M, CEBRIAN SILLA A, BRAMBILLA E, MUSELLA A, DE CEGLIA R, TENEUD L, DE CHIARA V, D’ADAMO P, GARCIA-VERDUGO JM, COMI G, MUZIO L, QUATTRINI A, LEOCANI L, MACCARRONE M, CENTONZE D, MARTINO G. Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitoxicity. Brain 2012;115:3320-3335 [Epub ahead of print on Sep. 24, 2012]. (*equally contributed)

LATERZA C, MERLINI A, DE FEO D, RUFFINI F, MENON R, ONORATI M, FREDRICKX E, MUZIO L, LOMBARDO A, COMI G, QUATTRINI A, TAVEGGI AC, FARINA C, CATTANEO E, MARTINO G. iPSC-derived neural precursors exert a neuroprotective role in immune-mediated demyelination via the secretion of leukemia inhibitory factor. Nat. Commun. 2013;4:2597.

ARNÒ B, GRASSIVARO F, ROSSI C, BERGAMASCHI A, GRETER M, FAVARO R, COMI G, BECHER B, MARTINO G*, MUZIO L*. Neural progenitors cells orchestrate microglia migration and positioning into the developing cortex. Nat. Comm. 2014;5:5611 doi: 10.1038/ncomms6611 (*equally contributed)

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Studies on all branches of neurosciences covering both research and clinical problems of neuroscientific interest.

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