Oct 23, 2018 Last Updated 12:11 PM, Oct 16, 2018

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Head, Neuroimmunology Unit
Laboratorio di Neuroimmunologia
Istituto Neurologico Nazionale 'C. Mondino' - Università di Pavia


Collaboratori
Elisabetta Zardini, biologa laboratorio
Silvia Romagnolo, tecnica di laboratorio, borsista

Via Mondino 2
27100 Pavia - Italia
Tel. 0382 380365
Fax 0382 380286
This email address is being protected from spambots. You need JavaScript enabled to view it.
www.mondino.it


Keywords su ambiti di competenza
sclerosi multipla, liquido cerebrospinale, autoimmunità, biomarkers, diagnostica di laboratorio delle malattie neurologiche


Tecniche utilizzate
isoelettrofocusing, ELISA, microscopio a fluorescenza, Western blot, elettroforesi verticale, teased nerves, colture cellulari, cell based assays


Pubblicazioni (a più alto impact factor negli ultimi 5 anni)

Probst C, Komorowski L, de Graaff E, van Coevorden-Hameete M, Rogemond V, Honnorat J, Sabeter L, Graus F, Jarius S, Voltz R, Wildemann B, Franciotta D, Blöcker IM, Schlumberger W, Stöcker W, Sillevis Smitt PA. Standardized test for anti-Tr/DNER in patients with paraneoplastic cerebellar degeneration. Neurol Neuroimmunol Neuroinflamm 2015;2(2):e68.

Kuhle J, Disanto G, Dobson R, et al., Franciotta D, et al., Comi G, Ramagopalan S, Giovannoni G. Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study. Mult Scler 2015 [Epub ahead of print]

Gnanapavan S, Hegen H, Khalil M, Hemmer B, Franciotta D, Hughes S, Hintzen R, Jeromin A, Havrdova E, Tumani H, Bertolotto A, Comabella M, Frederiksen J, Alvarez-Cermeño JC, Villar L, Galimberti D, Myhr KM, Dujmovic I, Fazekas F, Ionete C, Menge T, Kuhle J, Keir G, Deisenhammer F, Teunissen C, Giovannoni G. Guidelines for uniform reporting of body fluid biomarker studies in neurologic disorders. Neurology 2014;83:1210-1216.

Jarius S1, Paul F, Fechner K, Ruprecht K, Kleiter I, Franciotta D, Ringelstein M, Pache F, Aktas O, Wildemann B. Aquaporin-4 antibody testing: direct comparison of M1-AQP4-DNA-transfected cells with leaky scanning versus M23-AQP4-DNA-transfected cells as antigenic substrate. J Neuroinflammation 2014;11:129.

Mancuso R, Franciotta D, Rovaris M, Caputo D, Sala A, Hernis A, Agostini S, Calvo M, Clerici M. Effects of natalizumab on oligoclonal bands in the cerebrospinal fluid of multiple sclerosis patients: A longitudinal study. Mult Scler 2014;(14):1900-3

Benedetti L, Franciotta D, Beronio A, Delucchi S, Capellini C, Sette MD. Meningoencephalitis-like onset of post-infectious AQP4-IgG-positive optic neuritis complicated by GM1-IgG-positive acute polyneuropathy. Mult Scler. 2014 (2):246-8.

Della-Torre E, Galli L, Franciotta D et al. Diagnostic value of IgG4 Indices in IgG4-related hypertrophic pachymeningitis. J Neuroimmunol. 2014 Jan 15;266(1-2):82-6.

Della-Torre E, Passerini G, Furlan R, Roveri L, Chieffo R, Anzalone N, Doglioni C, Zardini E, Sabbadini MG, Franciotta D. Cerebrospinal fluid analysis in immunoglobulin G4-related hypertrophic pachymeningitis. J Rheumatol. 2013 Nov;40(11):1927-9.

Benedetti L, Facco M, Franciotta D, Dalla Torre C, Campagnolo M, Lucchetta M, Boscaro E, Ermani M, Del Sette M, Berno T, Candiotto L, Zambello R, Briani C. NK cells and their receptors in naive and rituximab-treated patients with anti-MAG polyneuropathy. J Neurol Sci. 2013 Aug 15;331(1-2):86-9

Teunissen C, Menge T, Altintas A, Alvarez-Cermeño JC, Bertolotto A, Berven FS, Brundin L, Comabella M, Degn M, Deisenhammer F, Fazekas F, Franciotta D, Frederiksen JL, Galimberti D, Gnanapavan S, Hegen H, Hemmer B, Hintzen R, Hughes S, Iacobaeus E, Kroksveen AC, Kuhle J, Richert J, Tumani H, Villar LM, Drulovic J, Dujmovic I, Khalil M, Bartos A. Consensus definitions and application guidelines for control groups in cerebrospinal fluid biomarker studies in multiple sclerosis. Mult Scler. 2013 Nov;19(13):1802-9.

Marchioni E, Ravaglia S, Montomoli C, Tavazzi E, Minoli L, Baldanti F, Furione M, Alfonsi E, Bergamaschi R, Romani A, Piccolo L, Zardini E, Bastianello S, Pichiecchio A, Ferrante P, Delbue S, Franciotta D, Bono G, Ceroni M. Postinfectious neurologic syndromes: a prospective cohort study. Neurology. 2013 Mar 5;80(10):882-9.

Pieragostino D, Del Boccio P, Di Ioia M, Pieroni L, Greco V, De Luca G, D'Aguanno S, Rossi C, Franciotta D, Centonze D, Sacchetta P, Di Ilio C, Lugaresi A, Urbani A Oxidative modifications of cerebral transthyretin are associated with multiple sclerosis. Proteomics. 2013 Mar;13(6):1002-9.

Kroksveen AC, Aasebø E, Vethe H, Van Pesch V, Franciotta D, Teunissen CE, Ulvik RJ, Vedeler C, Myhr KM, Barsnes H, Berven FS. Discovery and initial verification of differentially abundant proteins between multiple sclerosis patients and controls using iTRAQ and SID-SRM. J Proteomics. 2013 Jan 14;78:312-25.

Di Filippo M, Franciotta D, Massa R, Di Gregorio M, Zardini E, Gastaldi M, Terracciano C, Rastelli E, Gaetani L, Iannone A, Menduno P, Floridi P, Sarchielli P, Calabresi P. Recurrent hyperCKemia with normal muscle biopsy in a pediatric patient with neuromyelitis optica. Neurology. 2012 Sep 11;79(11):1182-4.

Pisani V, Stefani A, Pierantozzi M, Natoli S, Stanzione P, Franciotta D, Pisani A. Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson's disease. J Neuroinflammation. 2012 Aug 8;9:188.

Jarius S, Franciotta D, Paul F, Bergamaschi R, Rommer PS, Ruprecht K, Ringelstein M, Aktas O, Kristoferitsch W, Wildemann B. Testing for antibodies to human aquaporin-4 by ELISA: sensitivity, specificity, and direct comparison with immunohistochemistry. J Neurol Sci. 2012 Sep 15;320(1-2):32-7.

Ferrò MT, Franciotta D, Prelle A, Bestetti A, Cinque P. Active intrathecal herpes simplex virus type 1 (HSV-1) and human herpesvirus-6 (HHV-6) infection at onset of multiple sclerosis. J Neurovirol. 2012 Oct;18(5):437-40.

Mallucci G, Franciotta D, Romani A, Ceroni M, Bergamaschi R. Anti-aquaporin-4 antibody-positive recurrent isolated optic neuritis and primary Sjögren's syndrome. J Neurol. 2012 Aug;259(8):1740-1.

Jarius S, Paul F, Franciotta D, de Seze J, Münch C, Salvetti M, Ruprecht K, Liebetrau M, Wandinger KP, Akman-Demir G, Melms A, Kristoferitsch W, Wildemann B. Neuromyelitis optica spectrum disorders in patients with myasthenia gravis: ten new aquaporin-4 antibody positive cases and a review of the literature. Mult Scler. 2012 Aug;18(8):1135-43.

Olivieri S, Conti A, Iannaccone S, Cannistraci CV, Campanella A, Barbariga M, Codazzi F, Pelizzoni I, Magnani G, Pesca M, Franciotta D, Cappa SF, Alessio M. Ceruloplasmin oxidation, a feature of Parkinson's disease CSF, inhibits ferroxidase activity and promotes cellular iron retention. J Neurosci. 2011 Dec 14;31(50):18568-77.

Menon R, Di Dario M, Cordiglieri C, Musio S, La Mantia L, Milanese C, Di Stefano AL, Crabbio M, Franciotta D, Bergamaschi R, Pedotti R, Medico E, Farina C Gender-based blood transcriptomes and interactomes in multiple sclerosis: involvement of SP1 dependent gene transcription. J Autoimmun. 2012 May;38(2-3):J144-55.

Teunissen CE, Tumani H, Bennett JL, Berven FS, Brundin L, Comabella M, Franciotta D, Federiksen JL, Fleming JO, Furlan R, Hintzen RQ, Hughes SG, Jimenez CR, Johnson MH, Killestein J, Krasulova E, Kuhle J, Magnone MC, Petzold A, Rajda C, Rejdak K, Schmidt HK, van Pesch V, Waubant E, Wolf C, Deisenhammer F, Giovannoni G, Hemmer B. Consensus Guidelines for CSF and Blood Biobanking for CNS Biomarker Studies. Mult Scler Int. 2011;2011:246412.

Costa A, Bini P, Hamze-Sinno M, Moglia A, Franciotta D, Sinforiani E, Ravaglia S, Bole-Feysot C, Hökfelt T, Déchelotte P, Fetissov SO.Galanin and α-MSH autoantibodies in cerebrospinal fluid of patients with Alzheimer's disease. J Neuroimmunol. 2011 Dec 15;240-241:114-20.

Jarius S, Paul F, Franciotta D, Ruprecht K, Ringelstein M, Bergamaschi R, Rommer P, Kleiter I, Stich O, Reuss R, Rauer S, Zettl UK, Wandinger KP, Melms A, Aktas O, Kristoferitsch W, Wildemann B Cerebrospinal fluid findings in aquaporin-4 antibody positive neuromyelitis optica: results from 211 lumbar punctures. J Neurol Sci. 2011 Jul 15;306(1-2):82-90.

Jarius S, Jacobi C, de Seze J, Zephir H, Paul F, Franciotta D, Rommer P, Mader S, Kleiter I, Reindl M, Akman-Demir G, Seifert-Held T, Kristoferitsch W, Melms A, Wandinger KP, Wildemann B. Frequency and syndrome specificity of antibodies to aquaporin-4 in neurological patients with rheumatic disorders. Mult Scler. 2011 Sep;17(9):1067-73.

Franciotta D, Zardini E, Caporali R, Piccolo L, Alberici E, Romani A, Bergamaschi R, Marchioni E, Ceroni M, Piccolo G. Systemic sclerosis in aquaporin-4 antibody-positive longitudinally extensive transverse myelitis. J Neurol Sci. 2011 Apr 15;303(1-2):139-41.

Benedetti L, Zardini E, Briani C, Beronio A, Gastaldi S, Jarius S, Mancardi GL, Schenone A, Franciotta D. B-cell-activating factor in rituximab-treated patients with anti-MAG polyneuropathy. J Neurol Neurosurg Psychiatry. 2011 Nov;82(11):1291-4.

Franciotta D, Di Stefano AL, Jarius S, Zardini E, Tavazzi E, Ballerini C, Marchioni E, Bergamaschi R, Ceroni M. Cerebrospinal BAFF and Epstein-Barr virus-specific oligoclonal bands in multiple sclerosis and other inflammatory demyelinating neurological diseases. J Neuroimmunol. 2011 Jan;230(1-2):160-3.

Scotti C, Sommi P, Pasquetto MV, Cappelletti D, Stivala S, Mignosi P, Savio M, Chiarelli LR, Valentini G, Bolanos-Garcia VM, Merrell DS, Franchini S, Verona ML, Bolis C, Solcia E, Manca R, Franciotta D, Casasco A, Filipazzi P, Zardini E, Vannini V. Cell-cycle inhibition by Helicobacter pylori L-asparaginase. PLoS One. 2010;9;5(11):e13892.

L'Episcopo F, Tirolo C, Testa N, Caniglia S, Morale MC, Cossetti C, D'Adamo P, Zardini E, Andreoni L, Ihekwaba AE, Serra PA, Franciotta D, Martino G, Pluchino S, Marchetti B. Reactive astrocytes and Wnt/β-catenin signaling link nigrostriatal injury to repair in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. Neurobiol Dis. 2011 Feb;41(2):508-27.

Jarius S, Frederikson J, Waters P, Paul F, Akman-Demir G, Marignier R, Franciotta D, Ruprecht K, Kuenz B, Rommer P, Kristoferitsch W, Wildemann B, Vincent A. Frequency and prognostic impact of antibodies to aquaporin-4 in patients with optic neuritis. J Neurol Sci. 2010 Nov 15;298(1-2):158-62.

Jarius S, Franciotta D, Paul F, Ruprecht K, Bergamaschi R, Rommer PS, Reuss R, Probst C, Kristoferitsch W, Wandinger KP, Wildemann B. Cerebrospinal fluid antibodies to aquaporin-4 in neuromyelitis optica and related disorders: frequency, origin, and diagnostic relevance. J Neuroinflammation. 2010 Sep 8;7:52.

D'Aguanno S, Franciotta D, Lupisella S, Barassi A, Pieragostino D, Lugaresi A, Centonze D, D'Eril GM, Bernardini S, Federici G, Urbani A. Protein profiling of Guillain-Barrè syndrome cerebrospinal fluid by two-dimensional electrophoresis and mass spectrometry. Neurosci Lett. 2010 Nov 12;485(1):49-54.

Benedetti L, Briani C, Franciotta D, Fazio R, Paolasso I, Comi C, Luigetti M, Sabatelli M, Giannini F, Mancardi GL, Schenone A, Nobile-Orazio E, Cocito D. Rituximab in patients with chronic inflammatory demyelinating polyradiculoneuropathy: a report of 13 cases and review of the literature. J Neurol Neurosurg Psychiatry. 2011 Mar;82(3):306-8.

Versino M, Biagi F, Bianchi PI, Zardini E, Colnaghi S, Moglia A, Corazza G, Franciotta D. Lancet Neurol 2010;9:653.

Lolli F, Franciotta D. Oligoclonal bands in tears. Mult Scler. 2010 Jun;16(6):760.

Jarius S, Franciotta D, Bergamaschi R, Wildemann B, Wandinger KP. Immunoglobulin M antibodies to aquaporin-4 in neuromyelitis optica and related disorders. Clin Chem Lab Med. 2010 May;48(5):659-63.

Franciotta D, Bestetti A, Sala S, Perucca P, Jarius S, Price RW, Di Stefano AL, Cinque P. Broad screening for human herpesviridae DNA in multiple sclerosis cerebrospinal fluid and serum. Acta Neurol Belg. 2009 Dec;109(4):277-82.

Jarius S, Probst C, Borowski K, Franciotta D, Wildemann B, Stoecker W, Wandinger KP.Standardized method for the detection of antibodies to aquaporin-4 based on a highly sensitive immunofluorescence assay employing recombinant target antigen. J Neurol Sci. 2010 Apr 15;291(1-2):52-6.

Teunissen CE, Tumani HT, Bennett JL, Berven FS, Brundin L, Comabella M, Franciotta D, et al. Short commentary on 'a consensus protocol for the standardization of cerebrospinal fluid collection and biobanking’. Mult Scler 2010;16:129-32.

Teunissen CE, Petzold A, Bennett JL, Berven FS, Brundin L, Comabella M, Franciotta D, Frederiksen JL, Fleming JO, Furlan R, Hintzen RQ, Hughes SG, Johnson MH, Krasulova E, Kuhle J, Magnone MC, Rajda C, Rejdak K, Schmidt HK, van Pesch V, Waubant E, Wolf C, Giovannoni G, Hemmer B, Tumani H, Deisenhammer F. A consensus protocol for the standardization of cerebrospinal fluid collection and biobanking. Neurology. 2009 Dec 1;73(22):1914-22.

Petzold A, Altintas A, Andreoni L, Bartos A, Berthele A, Blankenstein MA, Buee L, Castellazzi M, Cepok S, Comabella M, Constantinescu CS, Deisenhammer F, Deniz G, Erten G, Espiño M, Fainardi E, Franciotta D, et al. Neurofilament ELISA validation. J Immunol Methods. 2010 Jan 31;352(1-2):23-31.

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