Head, Immunobiology of Neurological Disorders Unit
Divisione di Neuroscienze
Istituto di Neurologia Sperimentale, Ospedale San Raffaele


Collaboratori
Emanuela Colombo, biotechnologist, post-doc
Marco Di Dario, biologist, Specialized in Pathology
Sundararajan Srinivasan, bioinformatician, PhD student
Alessandra Russo, Biologist, fellow
Anthea De Angelis, biologist, fellow
Daniela Triolo, PhD, Technician


Via Olgettina 58
20132 Milano – Italia
02 264 361 80
farina.cinthia@hsr.it
www.hsr.it/ricerca/divisioni-centri-istituti-e-programmi-di-ricerca/istituto-di-neurologia-sperimentale-inspe/cinthia-farina/


Keywords su ambiti di competenza
Multiple Sclerosis and EAE, glia cell biology, neurodegeneration, innate and adaptive immunity, bioinformatics and systems biology, neurotrophic factors, skeletal muscle.


Tecniche utilizzate
Molecular and cellular biology of glial/neuronal/immune cells. Functional genomics and bioinformatics. Histology of lymphoid, skeletal and nervous tissue. Experimental mouse models.


Recent Publications

  1. Emanuela Colombo, Stefania Romaggi, Marina Mora, Lucia Morandi and Cinthia Farina. A role for inflammatory mediators in the modulation of the neurotrophin receptor p75NTR on human muscle precursor cells. J. Neuroimmunol. 243, 2012.
  2. Emanuela Colombo, Chiara Cordiglieri, Giorgia Melli, Jia Newcombe, Markus Krumbholz, Luis Parada, Enzo Medico, Reinhard Hohlfeld, Edgar Meinl and Cinthia Farina. Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration. J.Exp. Med. 209, 2012.
  3. Ramesh Menon, Marco Di Dario, Chiara Cordiglieri, Silvia Musio, Loredana La Mantia, Clara Milanese, Anna Luisa Di Stefano, Massimo Crabbio, Diego Franciotta, Roberto Bergamaschi, Rosetta Pedotti, Enzo Medico and Cinthia Farina. Gender-based blood transcriptomes and interactomes in multiple sclerosis: Involvement of SP1 dependent gene transcription. J. Autoimmunity 38, 2012.
  4. Emanuela Colombo, Stefania Romaggi, Flavia Blasevich, Marina Mora, Chiara Falcone, Hanns Lochmüller, Lucia Morandi and Cinthia Farina. The neurotrophin receptor p75NTR is induced on mature myofibers in inflammatory myopathies and promotes myotube survival to inflammatory stress. Neuropath. Appl. Neurobiol. 38, 2012.
  5. Emanuela Colombo, Francesco Bedogni, Isabella Lorenzetti, Nicoletta Landsberger, Stefano C. Previtali and Cinthia Farina. Autocrine and immune cell derived BDNF in human skeletal muscle: implications for myogenesis and tissue regeneration. J. Pathology 231 (2), 2013.
  6. Emanuela Colombo, Paolo Tentorio, Silvia Musio, Klaus Rajewsky, Rosetta Pedotti, Stefano Casola and Cinthia Farina. Skewed B cell differentiation affects lymphoid organogenesis but not T-cell mediated autoimmunity. Clin Exp Immunol. 176, 2014.
  7. Emanuela Colombo, Marco Di Dario, Eleonora Capitolo, Linda Chaabane, Jia Newcombe, Gianvito Martino and Cinthia Farina. Fingolimod may support neuroprotection via blockade of astrocyte nitric oxide. Annals Neurol. 2014.
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