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AINI Press Review

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    • 3 MARCH 2021
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    IL-17 controls central nervous system autoimmunity through the intestinal microbiome

    IL-17 controls central nervous system autoimmunity through the intestinal microbiome

    Abstract: “Remote memories depend on coordinated activity in the hippocampus and frontal cortices, but the timeline of these interactions is debated. Astrocytes sense and modify neuronal activity, but their role in remote memory is scarcely explored. We…

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    • 2 OCTOBER 2020
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    Interleukin-26, preferentially produced by TH17 lymphocytes, regulates CNS barrier function.

    Interleukin-26, preferentially produced by TH17 lymphocytes, regulates CNS barrier function.

    Results: IL-26 expression was induced in TH lymphocytes by TH17-inducing cytokines and was upregulated in the blood and CSF of patients with MS. CD4+IL-26+ T lymphocytes were found in perivascular infiltrates in MS brain lesions, and both receptor chains for…

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    • 25 SEPTEMBER 2020
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    Astrocytes contribute to remote memory formation by modulating hippocampal-cortical communication during learning.

    Astrocytes contribute to remote memory formation by modulating hippocampal-cortical communication during learning.

    “Remote memories depend on coordinated activity in the hippocampus and frontal cortices, but the timeline of these interactions is debated. Astrocytes sense and modify neuronal activity, but their role in remote memory is scarcely explored. We expressed…

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    • AINI Secretariat
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    • 28 SEPTEMBER 2020
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    B cell rich meningeal inflammation associates with increased spinal cord pathology in multiple sclerosis.

    B cell rich meningeal inflammation associates with increased spinal cord pathology in multiple sclerosis.

    “Increased inflammation in the cerebral meninges is associated with extensive subpial cortical grey matter pathology in the forebrain and a more severe disease course in a substantial proportion of secondary progressive multiple sclerosis (SPMS) cases….

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