An immune-cell signature marks the brain in Alzheimer’s disease

Sphingolipid metabolism in cancer signalling and therapy

For decades, research into Alzheimer’s disease has centred on neurons. Only in the past few years have scientists identified a role for immune cells in the progression of this neurodegenerative disorder1. Most research has focused on the nonspecific, innate branch of the immune system. Gate et al. report that an immune-cell subpopulation belonging to the adaptive immune system — which remembers and responds to specific foreign invaders — might also have a role in Alzheimer’s disease.

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Original paper: Gate et al., 2020

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