Chimeric autoantibody receptor T cells deplete NMDA receptor-specific B cells

NMDAR encephalitis is characterized by the presence of specific autoantibodies that specifically target the NMDAR channel and have been shown to be pathogenic in various in vitro and in vivo models. Reincke et Al. developed a CAAR NMDAR which permit to eliminate selective B cells that produce NMDAR autoantibodies. In detail, they developed a CAAR

Announcement of Call for applications 2024 Joseph Altman Award in Developmental Neuroscience

The Japan Neuroscience Society is now announcing the call for nominations for the 2024 Joseph Altman Award, and will accept applications from all over the world. Application submission site opens on November 1st, 2023. Application deadline is on January 31st, 2024 For more information on the Altman Award click HERE

Analysis of inflammatory markers and tau deposits in an autopsy series of nine patients with anti‐IgLON5 disease

Analysis of inflammatory markers and tau deposits in an autopsy series of nine patients with anti‐IgLON5 disease IgLON5 antibodies associated disorder is characterized neuropathologically by the deposition of TAU protein in the hypothalamus and tegmentum of the brainstem. In this cutting-edge work Berger-Sieczkowski et Al., sought to understand whether the chicken or the egg comes

PD-L1 positive astrocytes attenuate inflammatory functions of PD-1 positive microglia in models of autoimmune neuroinflammation

Astrocytes plays an important role during neuroinflammatory conditions, because depending to CNS micromilieu, can promote or inhibit several pathological processes. Linnerbauer et Al. studied the features of the astrocytes that upregulate PD-L1 in multiple sclerosis (MS) demonstrating that: During the peak of experimental autoimmune encephalomyelitis (EAE) astrocytes are the glial cells that most upregulates PD-L1.

Save the date per il Winter School: diagnostica neuroimmunologica di laboratorio

Il Winter School: diagnostica neuroimmunologica di laboratorio si terrà a Trento il 11 e 13 dicembre 2023. L’AINI ha deciso di organizzare, nel dicembre 2023, un corso pratico di diagnostica delle malattie neuroimmunologiche presso l’Università di Trento. Il corso sarà incentrato sulle patologie autoimmuni del sistema nervoso centrale e periferico, quali la neuromielite ottica, le

B cell depletion therapy does not resolve chronic active multiple sclerosis lesions

Chronic active lesions (CAL), a neuropathological finding of multiple sclerosis (MS), are a very important predictors of severity and progression of the disease, including progression independent of relapse activity (PIRA). In the other hand, a possibility to study “in vivo” the CAL is the evaluation of paramagnetic rim lesions (PRL) which can be detected using