BATOCCHI ANNA PAOLA

Research themes
Multiple sclerosis, biological markers of disease activity, role of neurotrophic factors, leptin and transcription factors in the pathogenesis of MS, autoimmune encephalomyelitis

Keywords
Multiple sclerosis, neurotrophic factors, leptin, transcription factors, cytokines

Methods
ELISA, RIA, Flow Cytometry, Cell biology, molecular biology, immunohistochemistry, Western blotting

Composition of the research group

• Anna Paola Batocchi Neurologist
  Università Cattolica del Sacro Cuore
• Massimiliano Mirabella Neurologist
  Università Cattolica del Sacro Cuore
• Marcella Caggiula Neurologist
  Fondazione Don Gnocchi, Roma
• Giovanni Frisullo Neurologist
  Università Cattolica del Sacro Cuore
• Viviana Nociti Resident in Neurology
  Università Cattolica del Sacro Cuore
• Agata Katia Patanella Resident in Neurology
  Università Cattolica del Sacro Cuore
• Cristina Sancricca Resident in Neurology
  Università Cattolica del Sacro Cuore
• Raffaele Iorio Resident in Neurology
  Università Cattolica del Sacro Cuore
• Francesco Angelucci Biologist
  Università Cattolica del Sacro Cuore

Recent publications

1. Frisullo G, Angelucci F, Caggiula M, Nociti V, Iorio R , Patanella AK, Sancricca C, Mirabella M, Tonali PA, Batocchi AP. pSTAT1, pSTAT3 and T-bet expression in peripheral blood mononuclear cells from Relapsing-Remitting Multiple Sclerosis patients correlates with disease activity. J Neurosci Res 2006 Jul 24; [Epub ahead of print]
   
   
2. Quaranta L, Batocchi AP, Sabatelli M, Nociti V, Tartaglione T, Quonzo F, Tonali PA. Monophasic demyelinating disease of central nervous system associated with Hepatitis A infection. J Neurol. 2006; 253(7):944-5.
   
   
3. Mariotti P, Colosimo C, Frisullo G, Caggiula M, Della Marca G, Valentini P, Baranello G, Tonali PA, Batocchi AP Gilden DH. Relapsing demyelinating disease triggered by chickenpox in a child. Neurology 2006, 66: 1953-1954
   
   
4. Mirabella M, Cianfoni A, Bucci M, Nociti V, Sancricca C, Patanella AK, Gasbarrini A, Ricci E, Lauriola L, Frisullo G, Tonali PA, Batocchi AP. Coeliac disease presenting with acute disseminated encephalomyelitis. Eur. J. Neurol. 2006, 13(2):202-3.
   
   
5. Caggiula M, Batocchi AP, Frisullo G, Angelucci F, Patanella AK, Sancricca C, Nociti V, Tonali PA, Mirabella M. Neurotrophic factor in relapsing remitting and secondary progressive multiple sclerosis patients during interferon beta therapy. Clin Immunol 2006;118(1):77-82.
   
   
6. Caggiula M, Batocchi AP, Frisullo G, Angelucci F, Patanella AK, Sancricca C, Nociti V, Tonali PA, Mirabella M. Neurotrophic factor and clinical recovery in relapsing-remitting multiple sclerosis. Scand J Immunol 2005 62(2):176-182
   
   
7. Nociti V, Cianfoni A, Mirabella M, Caggiula M, Frisullo G, Patanella AK, Sancricca C, Angelucci F, Tonali PA, Batocchi AP. Clinical characteristics, course and prognosis of Spinal Multiple Sclerosis. Spinal Cord 2005, 43(12):731-4.
   
   
8. Angelucci F, Mirabella M, Caggiula M, Frisullo G, Patanella K, Sancricca C, Nociti V, Tonali PA, Batocchi AP. Evidence of involvement of leptin and IL-6 peptides in the action of interferon-beta in secondary progressive multiple sclerosis. Peptides 2005, 26(11): 2289-93
   
   
9. Angelucci F, Mirabella M, Frisullo G, Caggiula M, Tonali PA., Batocchi AP. Serum levels of anti-myelin antibodies in relapsing-remitting multiple sclerosis patients during different phases of disease activity and immunomodulatory therapy. Disease Markers 2005 21(2): 49-55.
   
   
10. Mariotti P, Batocchi AP, Colosimo C, Cattani P, Stefanini MC, Colitto F, Tonali P, Guzzetta F. Positive PCR for enterovirus in the cerebrospinal fluid of a child with acute disseminated encephalomyelitis. J Neurol 2004, 251(10):1267-9
    
    
11. Frisullo G, Angelucci F, Mirabella M, Caggiula M, Patanella K, Nociti V, Tonali PA, Batocchi AP. Leptin enhances the release of cytokines by peripheral blood mononuclear cells from relapsing Multiple Sclerosis patients. J Clin Immunol 2004, 24 (3): 286-292
    
    
12. Batocchi AP, Rotondi M, Caggiula M, Frisullo G, Odoardi F, Nociti V, Carella C, Tonali PA, Mirabella M. Leptin as marker of multiple sclerosis activity in patient treated with interferon-beta. J Neuroimmunol 2003 Jun; 139(1-2):150-154
    
    
13. Mariotti P, Batocchi AP, Colosimo C, Lo Monaco M, Caggiula M, Colitto F, Tonali PA, Guzzetta F. Multiphasic demyelinating disease involving central and peripheral nervous system in a child. Neurology. 2003 Jan 28;60(2):348-9
    
    
14. Batocchi AP, Della Marca G, Mirabella M, Caggiula M, Frisullo G, Mennuni GF, Tonali PA. Relapsing-remitting autoimmune agrypnia. Ann Neurol 2001 Nov; 50: 668-671