Apr 24, 2018 Last Updated 10:38 AM, Apr 20, 2018

Microglia contribute to the maintenance of BBB integrity

Published in News
Read 919 times
Rate this item
(0 votes)

Microglia are integral functional elements of the central nervous system, but the contribution of these cells to the structural integrity of the neurovascular unit has not hitherto been assessed. We show here that following blood–brain barrier (BBB) breakdown, P2RY12 (purinergic receptor P2Y, G-protein coupled, 12)-mediated chemotaxis of microglia processes is required for the rapid closure of the BBB. Mice treated with the P2RY12 inhibitor clopidogrel, as well as those in which P2RY12 was genetically ablated, exhibited significantly diminished movement of juxtavascular microglial processes and failed to close laser-induced openings of the BBB. Thus, microglial cells play a previously unrecognized protective role in the maintenance of BBB integrity following cerebrovascular damage. Because clopidogrel antagonizes the platelet P2Y12 receptor, it is widely prescribed for patients with coronary artery and cerebrovascular disease. As such, these observations suggest the need for caution in the postincident continuation of P2RY12-targeted platelet inhibition.

Lou et al.
PNAS; October 2015

Full Text

Last modified on Sunday, 24 January 2016 17:09
Login to post comments

Registered area

Thanks to the support of
merck serono biogen sanofi

Conferences & Courses

17° Corso CRNI Viva la differenza: sesso e neuroimmunologia

March 7-10, 2018 
Bergamo - Bergamo Science Center


Encefaliti Autoimmuni e Malattie Demielinizzanti Atipiche

16 febbraio 2018
Aula Magna Giorgio De Sandre


JNIInternational Brain Research Organization
Bringing Neuroscience to the World
JNIJournal of Neuroimmunology
Studies on all branches of neurosciences covering both research and clinical problems of neuroscientific interest.

This website or its third party tools use cookies, which are necessary to its functioning and required to achieve the purposes illustrated in the cookie policy. If you want to know more or withdraw your consent to all or some of the cookies, please refer to the cookie policy. By closing this banner, scrolling this page, clicking a link or continuing to browse otherwise, you agree to the use of cookies. To find out more about the cookies we use and how to delete them, see our Cookie Policy