Jul 20, 2019 Last Updated 10:53 AM, Jul 6, 2019

Intermittent fasting confers protection in CNS autoimmunity by altering the gut microbiota

Published in News
Read 484 times
Rate this item
(0 votes)

Gut microbiota has been linked to several physiological and immune-related functions as well as it has been widely proven that the variety of microbes that inhabit human intestine can be influenced by social and dietary habits, as well as by chronical conditions such as diabetes. Furthermore, alterations or imbalances of the microbiota has often been theorized - although never unequivocally proven - as an important factor in the pathogenesis of several inflammatory conditions, including multiple sclerosis (SM); this fact, in particular, has been recently corroborated by the observation that the microbiota of MS patients differs significantly from that of their healthy counterpart. 

The authors of this paper, Franesca Cignella et al., had previously demonstrated that intermittent fasting (IF), is beneficial on the murine model of MS, i.e. experimental autoimmune encephalomyelitis (EAE), and decided to further investigate this strategy in order to understand whether its efficacy resides in the modulation of the gut flora; they also performed a small controlled randomized trial to understand if the same results can be observed when IF is applied to MS patients.

IF was able to induce significant changes in mouse microbiota that, once transfered to EAE, were protective in this model as they ameliorated clinical score, T cell pathogenetical features and the overall inflammatory status in these mice. Quite importantly, IF also was able to ameliorate the clinical condition in relapse-remitting MS patients.

Source: Cell metabolism

Last modified on Friday, 14 December 2018 13:05
Login to post comments

Registered area

Thanks to the support of
merck serono biogen sanofi

Conferences & Courses

17° Corso CRNI Viva la differenza: sesso e neuroimmunologia

March 7-10, 2018 
Bergamo - Bergamo Science Center


Encefaliti Autoimmuni e Malattie Demielinizzanti Atipiche

16 febbraio 2018
Aula Magna Giorgio De Sandre


JNIInternational Brain Research Organization
Bringing Neuroscience to the World
JNIJournal of Neuroimmunology
Studies on all branches of neurosciences covering both research and clinical problems of neuroscientific interest.

This website or its third party tools use cookies, which are necessary to its functioning and required to achieve the purposes illustrated in the cookie policy. If you want to know more or withdraw your consent to all or some of the cookies, please refer to the cookie policy. By closing this banner, scrolling this page, clicking a link or continuing to browse otherwise, you agree to the use of cookies. To find out more about the cookies we use and how to delete them, see our Cookie Policy