Aug 15, 2018 Last Updated 12:13 PM, Aug 1, 2018

Estrogen receptor is involved in increased prevalence of autoimmune diseases in women

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More than 75% of autoimmune diseases display increased prevalence in women, and estrogens have been often pointed out as possible responsible due to their involvement in a rather wide number of physiological functions, including immune ones. However, to date, the role of estrogens in immune reactions, especially T-dependent ones, is still not well understood.

 

In this study, published on  Science Signaling, Imram Mohammad and Inna Starskaia and colleagues developed a murine model of colitis with estrogen receptor alpha-deficent mice: these mice displayed reduced TH1 and TH17 function (activation, survival and proliferation) as well as increased Treg activity.

Source: Science Signaling

Last modified on Friday, 06 July 2018 15:13
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