The transcription factor FoxP3 is endowed with the ability to repress conventional T cell phenotype while promoting Treg immunoregulatory properties by binding several specific sequences on the genome of T lymphocytes. However, understanding the mechanism by which this myriad of signals is coordinated in Tregs is no easy task, partly due to the fact that the signature genes targeted by FoxP3 represent only a small portion of the sequences actually recognized by this transcription factor on the whole genome; to make things harder, FoxP3 also directly interacts with a huge host of other different transcription factors. The integration of all these signals is behind Treg phenotype and is, to date, still poorly understood.
The 41st Annual Meeting of Japan Neurscience Society (Neuroscience 2018) will be held at Kobe convention Center, Hyogo, Japan from July 26th to 29th, 2018.
The JNS is now annoucing the second call for application for the Altamn Award in Developmental Neuroscience.
The JNS also offers Travel Awards to enthusiastic leading non-Japanese investigators traveling from abroad to present high quality papers to the meeting.
Nelson Spruston and Jayaram Chandrashekar, two neuroscientists at the Howard Hughes Medical Institute (HHMI) Janelia Research Campus in Ashburn (Virginia), compiled this astonishing 3D map that tracks down the route of 302 (to date) neurons inside the mouse brain. The list should reach 1000 neurons by next year.
In a previous update (here's the link) we reported a compelling article from Nature News that discussed the caveats and possible fallacies of "classical" 0,05 p-value as a threshold to define significancy in experimental results.
In occasione del congresso annuale della SIN, Domenica 15 ottobre davanti a un folto pubblico è stato presentato il Supplemento "Standardizations and Guidelines in Clinical and Laboratory Neuroimmunology, della rivista Neurological Sciences
In this very interesting paper, prof. Ben A. Barres of Stanford University, gives his point of view concerning the adversities that postdocs must (but shouldn't) face as they try to get their own independence from their mentors.
Il 15 e il 16 dicembre 2017 presso UNA Hotel Modena (Baggiovara) si terrà il workshop Sclerososi Multipla: dall'immunologia all'innovazione terapeutica.
L'evento è patrocinato da AINI.
Brigitta Stockinger and Sara Omenetti review, in a rather extensive way, the double nature of TH17 cells of infamous promoters of immunopathological disorders and supporters of other phisiological and non-inflammatory processes.
Heidi Ledford summarizes the current situation regarding the clinical use of immunomodulatory cytokines as possible treatments in autoimmune diseases.
Science is apparently facing a "statistical" crisis, with lots of papers claiming results that fail to be reproduced by other labs.
A recent ruling by the European Court of Justice has alarmed clinicians and scientists all over the world due to the controversial decision of not considering solid "scientifical proof" as the only element in evaluating a possible connection between vaccines (or other clinical treatments) and diseases.
Vi proponiamo una recente intervista fatta al dott. Stefano Pluchino, riportata sul sito della Fondazione Italiana Sclerosi Multipla, riguardante gli ultimi risultati ottenuti dal suo gruppo presso il Wellcome Trust-MRC Stem Cell Institute di Cambridge (UK), composto, oltre che dal dott. Pluchino stesso, dai dottori Nunzio Iraci, Edoardo Gaude e Christian Frezza.
La ricerca riguarda future prospettive terapeutiche basate sugli exosomi prodotti dalle cellule staminali neuronali.
In this paper, Andrew g. Levine and collegues describe a quite peculiar class of Treg cells, stably expressing TH1 transcription factor Tbet, that seems to play a very important role in immune tolerance.
Regulatory T cells (Treg) and TH17 lymphocytes are, no doubt, crucial players in the course and outcome of inflammatory events, and their unbalance is suspected to be a major culprit in triggering many chronic and autoimmune conditions.
Guido Forni, Alberto Mantovani, Lorenzo Moretta e Giovanni Rezza hanno preparato, in occasione del decreto approvato pochi giorni fa, un rapporto di facile consultazione riguardante i vaccini ed il loro utilizzo nella prevenzione delle malattie infettive nella comunità.
Ne raccomandiamo la lettura e la più ampia diffusione.
In this rather comprehensive review, published in this month issue of Nature Immunology, Marc Veldhoen (Faculty of Medicine, Lisbon university) covers the biological effects of IL-17, its cellular sources, biological effects and role in inflammation, tumours and response to microbes.
Science gives us this elegant and accessible diagram, which represents a useful evidence-based tool in a time of rather controversial debate in our country.
John Bohannon, Science contributing correspondent, analyzes the studies done by social scientists about the way researchers travel all over the world as they follow new employments in different countries.
Owein Guillemot-Legris and Giulio G. Muccioli review the known evidences that connect obesity to neuroinflammation, a link - often underestimated - that represents one of the most serious issues of our time and that is heavily involved in the pathogenesis of many neurodegenerative conditions.
Dal 13 al 15 settembre 2017, l'auditorium dell'università degli studi Milano-Bicocca ospiterà il congresso NEUROMI 2017 International symposium: personalised medicine in multiple sclerosis.
Il congresso è stato patrocinato da AINI. La scadenza per la sottomissione degli abstract è stata prorogata al 15 giugno 2017.
Trovate tutte le informazioni sull'evento al link sottostante.
Dal 16 al 18 ottobre prossimo, si terrà a Napoli il corso EFIS/EJI "Tumour Immunology: from tissue microenvironment to immunotherapy".
In this beautiful paper, published just last week on NEJ, Dr Steri, Orrù and Idda et al. were able to identify in a variant of the TNFSF13B gene, which encode for B-cell activating factor (BAFF), a very important risk factor for multiple sclerosis as well as for lupus.
A recent study, published on Cell by Marteen Hulsmans et al., describes an interesting (as unexpected) feature of macrophages to add to their ever-growing "things in which they are involved" list.
In this recent study, published on Nature Medicine, Tamar L Ben-Shaanan et al. studied the link between the function of brain areas responsible for processing positive expectation (such as ventral tegmental area) and their effect on immune responses, deepening our understanding of the molecular bases for placebo effect.
Apparently, the job of a PhD is quite stressful, a recent study says.
A new study, published on Nature Communications by prof. Marcello D'Amelio's research group (Santa Lucia Foundation/Campus Bio-Medico, Rome), unveils new insights on the pathogenesis of Alzheimer's disease and opens new diagnostic perspectives.
Dr Panayiota Poirazi, chair of the FENS-Kavli Network of Excellence, analyzes the problems that european early- and mid-career scientists must face everyday as they try to obtain research funds, also suggesting the mechanisms of grant application and evaluation that funding agencies should improve to help young scientists build a career.