Sep 21, 2017 Last Updated 3:43 PM, Sep 20, 2017
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Per la prima volta al mondo un paziente affetto da sclerosi multipla cronica in stadio avanzato ha ricevuto una terapia a base di cellule staminali neurali presso l’unità operativa di Neurologia dell’IRCCS Ospedale San Raffaele di Milano. 

In this very interesting paper, prof. Ben A. Barres of Stanford University, gives his point of view concerning the adversities that postdocs must (but shouldn't) face as they try to get their own independence from their mentors.

 Sclerosi Multipla 2017

Il 15 e il 16 dicembre 2017 presso UNA Hotel Modena (Baggiovara) si terrà il workshop Sclerososi Multipla: dall'immunologia all'innovazione terapeutica
L'evento è patrocinato da AINI.
L'iscrizione è gratuita ma i posti sono limitati.

Brigitta Stockinger and Sara Omenetti review, in a rather extensive way, the double nature of TH17 cells of infamous promoters of immunopathological disorders and supporters of other phisiological and non-inflammatory processes.

 

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While working on lifespan-extending compounds, Gordon J. Lithgow, Monica Driscoll and Patrick Phillips faced one of the biggest fears in the life of a scientist, low reproducibility.

Heidi Ledford summarizes the current situation regarding the clinical use of immunomodulatory cytokines as possible treatments in autoimmune diseases.

 

Science is apparently facing a "statistical" crisis, with lots of papers claiming results that fail to be reproduced by other labs.

A recent ruling by the European Court of Justice has alarmed clinicians and scientists all over the world due to the controversial decision of not considering solid "scientifical proof" as the only element in evaluating a possible connection between vaccines (or other clinical treatments) and diseases.

Vi proponiamo una recente intervista fatta al dott. Stefano Pluchino, riportata sul sito della Fondazione Italiana Sclerosi Multipla, riguardante gli ultimi risultati ottenuti dal suo gruppo presso il Wellcome Trust-MRC Stem Cell Institute di Cambridge (UK), composto, oltre che dal dott. Pluchino stesso, dai dottori Nunzio Iraci, Edoardo Gaude e Christian Frezza.

La ricerca riguarda future prospettive terapeutiche basate sugli exosomi prodotti dalle cellule staminali neuronali.

In this paper, Andrew g. Levine and collegues describe a quite peculiar class of Treg cells, stably expressing TH1 transcription factor Tbet, that seems to play a very important role in immune tolerance. 

 

Regulatory T cells (Treg) and TH17 lymphocytes are, no doubt, crucial players in the course and outcome of inflammatory events, and their unbalance is suspected to be a major culprit in triggering many chronic and autoimmune conditions.

Guido Forni, Alberto Mantovani, Lorenzo Moretta e Giovanni Rezza hanno preparato, in occasione del decreto approvato pochi giorni fa, un rapporto di facile consultazione riguardante i vaccini ed il loro utilizzo nella prevenzione delle malattie infettive nella comunità.

Ne raccomandiamo la lettura e la più ampia diffusione.

 

 

In this rather comprehensive review, published in this month issue of Nature Immunology, Marc Veldhoen (Faculty of Medicine, Lisbon university) covers the biological effects of IL-17, its cellular sources, biological effects and role in inflammation, tumours and response to microbes.  

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Science gives us this elegant and accessible diagram, which represents a useful evidence-based tool in a time of rather controversial debate in our country.

John Bohannon, Science contributing correspondent, analyzes the studies done by social scientists about the way researchers travel all over the world as they follow new employments in different countries.

 

Owein Guillemot-Legris and Giulio G. Muccioli review the known evidences that connect obesity to neuroinflammation, a link - often underestimated - that represents one of the most serious issues of our time and that is heavily involved in the pathogenesis of many neurodegenerative conditions.

Dal 13 al 15 settembre 2017, l'auditorium dell'università degli studi Milano-Bicocca ospiterà il congresso NEUROMI 2017 International symposium: personalised medicine in multiple sclerosis.

Il congresso è stato patrocinato da AINI. La scadenza per la sottomissione degli abstract è stata prorogata al 15 giugno 2017.

Trovate tutte le informazioni sull'evento al link sottostante.

NEUROMI 2017

In this article, Evanna Mills, Beth Kelly and Luke O'Neill, review the features of the role played by mitochondria during both innate and adaptive immune responses.

Dal 16 al 18 ottobre prossimo, si terrà a Napoli il corso EFIS/EJI "Tumour Immunology: from tissue microenvironment to immunotherapy".

In this beautiful paper, published just last week on NEJ, Dr Steri, Orrù and Idda et al. were able to identify in a variant of the TNFSF13B gene, which encode for B-cell activating factor (BAFF), a very important risk factor for multiple sclerosis as well as for lupus. 

 

 

A recent study, published on Cell by Marteen Hulsmans et al., describes an interesting (as unexpected) feature of macrophages to add to their ever-growing "things in which they are involved" list.

 

In this recent study, published on Nature Medicine, Tamar L Ben-Shaanan et al. studied the link between the function of brain areas responsible for processing positive expectation (such as ventral tegmental area) and their effect on immune responses, deepening our understanding of the molecular bases for placebo effect. 

 

Apparently, the job of a PhD is quite stressful, a recent study says. 

 

 

A new study, published on Nature Communications by prof. Marcello D'Amelio's research group (Santa Lucia Foundation/Campus Bio-Medico, Rome), unveils new insights on the pathogenesis of Alzheimer's disease and opens new diagnostic perspectives.

Nature Conferences REGENERATION

  • Mar 23, 2017
  • Published in News

Dal 16 al 18 novembre 2017 il centro congressi San Raffaele di Milano ospiterà la Nature Conference sul tema della rigenerazione.

Dr Panayiota Poirazi, chair of the FENS-Kavli Network of Excellence, analyzes the problems that european early- and mid-career scientists must face everyday as they try to obtain research funds, also suggesting the mechanisms of grant application and evaluation that funding agencies should improve to help young scientists build a career.

 

La Fondazione italiana sclerosi multipla ha pubblicato il Bando FISM 2017 per il finanziamento di progetti di ricerca e borse di studio sulla sclerosi multipla. 

Stars are pretty

Being constantly updated is probably one of the most important parts of our job...

In this review, recently published on Science, Dr. Jonathan Kipnis summarizes the cellular and molecular mechanisms behind the role of lymphocytes in inducing and modulating immune tolerance in the CNS, with particular attention to the trafficking of immune cells and solubile factors throughout the meningeal lymphatic vessels and peripheral deep cervical lymph nodes.     

  

This week, Science highlights a recently published study that might link active type 2 herpes infection in early pregnancy with a doubled risk of autism in male children.

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Conferences & Courses

XXVII AINI Congress

May 7-10, 2018 
Trieste

 

Workshop Sclerosi Multipla: dall'immunologia all'innovazione …

December 15-16, 2017 
Modena (Baggiovara) - UNA Hotel Modena

Nature Conferences REGENERATION

November 16-18, 2017
Aula Caravella Santa Maria, San Raffaele Congress Centre, Milan, Itlay

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2nd Americas Schools of Neuroimmunology (ASNI)

October 3-6, 2017
Charlottesville (VA) - USA 

Go to the website

JNIInternational Brain Research Organization
Bringing Neuroscience to the World
JNIJournal of Neuroimmunology
Studies on all branches of neurosciences covering both research and clinical problems of neuroscientific interest.

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