Feb 22, 2018 Last Updated 10:55 AM, Feb 21, 2018
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Senior european corrispondent Alyson Abbot summarizes the difficult situation of italian scientific and academic environment in the final weeks before elections.

Microbiota has been recently emerging as an unexpectedly important partner in immune homeostasis and its disfunctions have been correlated to virtually every immunopathological condition.

This year AINI has issued a generous numbers of Grants, both for the XXVII Congress of the Italian Association of Neuroimmuniology (AINI 2018 - Trieste, May 7-10, 2018) and the 14th International Congress of Neuroimmunology (ISNI 2018 - Brisbane - Australia, August 27-31, 2018).

BRAYN Locandinadef02

The 1st Annual Scientific Meeting of the Italian Young Neuroscientists, BraYn (Brainstorming Research Assembly for Young Neuroscientists), which will be held in Genoa, Italy, during the 29th and 30th of June 2018, is inspired and organized by researchers under the age of 40 from different backgrounds and with different scientific approaches. The meeting aims establish connections between the future protagonists of Italian neuroscience.

BMAL1 gene is central in regulating circadian clock and rhythmic gene expression in mammal cells. However, its influence over physiological functions seems to be broader than expected, and it might be involved in unexpected pathways, including immune responses, since people displaying circadian disruptions are more prone to develop chronic inflammatory diseases.

Caroline E. Sutton and colleagues might have found the molecular machinery -or at least one of its important gears- of this mechanism, in this paper published on Nature Communication.

Low reproducibility is the greatest fear of every scientist, and, as a matter of fact, a plague in today's scientific research, with barely 40% of published data being considered reliably replicable

 

In the last issue of Lancet Neurology, Jeffrey Alan Thompson (University College, London, UK), and its group, proposed an update of the McDonald criteria used to diagnose multiple sclerosis. 

In a recent paper, published on PNAS, Oliver W. Griffith and colleagues investigated the mechanisms from which embryo implantation evolved.

March 7-10, 2018 
Bergamo - Bergamo Science Center

Il convegno è rivolto alla professione Medico Chirurgo, discipline: Neurologia e Allergologia e immunologia clinica, ed è accreditato ECM (18 crediti).

16 febbraio 2018 
Aula Magna Giorgio De Sandre
POLICLINICO UNIVERSITARIO G.B. ROSSI - Verona

Un breve video, che riporta i pareri e le testimonianze di Meredith Wadman, reporter per Science Magazine.

 

La multinazionale americana Pfizer frena sulla ricerca destinata alle patologie neurodegenerative e dirotta gli investimenti in aree in cui ha già raggiunto una forte leadership scientifica e il massimo impatto sui pazienti. Un disinvestimento da filoni importanti su Alzheimer e Parkinson che non hanno portato i frutti sperati, soprattutto nei tempi sperati. Lo ha dichiarato la stessa multinazionale, che ha anche annunciato un pesante impatto sul personale dedicato all’area delle demenze, con una riduzione totale dell’organico di circa 300 posizioni.

Continua a leggere l'articolo originale su Il Sole 24 Ore

 

Vaccines are, as a matter of fact, one of the greatest achievements ever obtained by human kind as they were able to eliminate infective diseases that, not too far in the past, were considered life-threatening menace or, quite often, a proper sentence to death. As a result, diseases such as tetanus or polio have become such a rare occurrence that, if on one hand the overall quality of life has improved significantly, on the other hand, the awareness of the perils represented by these infections (and the role played by vaccines in defeating them) has probably dwindled.

La Facoltà di Medicina e Chirurgia dell'Università di Modena e Reggio Emilia sta promuovendo degli incontri con gli studenti delle scuole medie superiori di Modena e Reggio Emilia sul tema delle vaccinazioni.

L'evento è patrocinato da AINI.

TNF receptors represent an important node of immune reactions, both innate and adaptive, and an important pharmacological target in the treatment of several autoimmune conditions. Their role has also been recently established in the regulation of Treg function, although the full extent and nature of the signals sprouting from the plethora of ligands that engage it is still poorly understood.

 

Mirela Kuka and Matteo Iannacone published last week a beautifully written review on B cells, their development, their interaction with viruses and the way cellular components of innate immunity can alter their function.

This week, Nature Reviews immunology published an interesting synopsis of the major 2017 discoveries regarding immunometabolism.

Five ways to fix statistics

  • Dec 01, 2017
  • Published in News

As debate rumbles on about how and how much poor statistics is to blame for poor reproducibility, Nature asked influential statisticians to recommend one change to improve science.

 

Published this month on Nature Reviews Immunology, this review represents an understandable and complete gathering of informations on the ontogenesis and involvement of CNS-resident microglia and peripheral macrophages in brain physiology and pathophysiology. 

The transcription factor FoxP3 is endowed with the ability to repress conventional T cell phenotype while promoting Treg immunoregulatory properties by binding several specific sequences on the genome of T lymphocytes. However, understanding the mechanism by which this myriad of signals is coordinated in Tregs is no easy task, partly due to the fact that the signature genes targeted by FoxP3 represent only a small portion of the sequences actually recognized by this transcription factor on the whole genome; to make things harder, FoxP3 also directly interacts with a huge host of other different transcription factors. The integration of all these signals is behind Treg phenotype and is, to date, still poorly understood. 

The 41st Annual Meeting of Japan Neurscience Society (Neuroscience 2018) will be held at Kobe convention Center, Hyogo, Japan from July 26th to 29th, 2018.

The JNS is now annoucing the second call for application for the Altamn Award in Developmental Neuroscience.
The JNS also offers Travel Awards to enthusiastic leading non-Japanese investigators traveling from abroad to present high quality papers to the meeting.

Nelson Spruston and Jayaram Chandrashekar, two neuroscientists at the Howard Hughes Medical Institute (HHMI) Janelia Research Campus in Ashburn (Virginia), compiled this astonishing 3D map that tracks down the route of 302 (to date) neurons inside the mouse brain. The list should reach 1000 neurons by next year.       

In a previous update (here's the link) we reported a compelling article from Nature News that discussed the caveats and possible fallacies of "classical" 0,05 p-value as a threshold to define significancy in experimental results. 

In occasione del congresso annuale della SIN, Domenica 15 ottobre davanti a un folto pubblico è stato presentato il Supplemento  "Standardizations and Guidelines in Clinical and Laboratory Neuroimmunology, della rivista Neurological Sciences

In this very interesting paper, prof. Ben A. Barres of Stanford University, gives his point of view concerning the adversities that postdocs must (but shouldn't) face as they try to get their own independence from their mentors.

 Sclerosi Multipla 2017

Il 15 e il 16 dicembre 2017 presso UNA Hotel Modena (Baggiovara) si terrà il workshop Sclerososi Multipla: dall'immunologia all'innovazione terapeutica
L'evento è patrocinato da AINI.

Brigitta Stockinger and Sara Omenetti review, in a rather extensive way, the double nature of TH17 cells of infamous promoters of immunopathological disorders and supporters of other phisiological and non-inflammatory processes.

 

460

 

While working on lifespan-extending compounds, Gordon J. Lithgow, Monica Driscoll and Patrick Phillips faced one of the biggest fears in the life of a scientist, low reproducibility.

Heidi Ledford summarizes the current situation regarding the clinical use of immunomodulatory cytokines as possible treatments in autoimmune diseases.

 

Science is apparently facing a "statistical" crisis, with lots of papers claiming results that fail to be reproduced by other labs.

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Conferences & Courses

17° Corso CRNI Viva la differenza: sesso e neuroimmunologia

March 7-10, 2018 
Bergamo - Bergamo Science Center

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Encefaliti Autoimmuni e Malattie Demielinizzanti Atipiche

16 febbraio 2018
Aula Magna Giorgio De Sandre
POLICLINICO UNIVERSITARIO G.B. ROSSI - Verona

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JNIInternational Brain Research Organization
Bringing Neuroscience to the World
JNIJournal of Neuroimmunology
Studies on all branches of neurosciences covering both research and clinical problems of neuroscientific interest.

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