Jun 27, 2019 Last Updated 10:21 AM, Jun 26, 2019

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Published in Research Units
Head, Experimental Neuroimmunology of CNS diseases - MD, PhD
Department of Clinical Neuroscience 
Fondazione Istituto Neurologico Carlo Besta

Collaboratori
Silvia Musio, Biologist, post-doc
Massimo Costanza, biotechnologist, post-doc



Recapiti

Via Amadeo 42
20133 Milano - Italia
02 23944654
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Keywords su ambiti di competenza
Inflammation, central nervous system, neurodegeneration, experimental autoimmune encephalomyelitis, innate and adaptive immunity, type 2 immunity, hormones.


Tecniche utilizzate
Experimental mouse models, gene knockout mouse models, molecular and cellular biology of immune cells, gene expression studies, flow cytometry, pharmacological studies.


Pubblicazioni rappresentative

1. Musio S, Costanza M, Poliani L, Fontana E, Cominelli M, Abolafio G, Steinman L, Pedotti R. Treatment with anti-FcεRIα antibody exacerbates EAE and T cell immunity against myelin. Neurology, Neuroimmunology and Neuroinflammation. 4:e342; Published online April 14, 2017 doi:10.1212/NXI.0000000000000342: 2332-7812. 
 
2. Rigoni R, Fontana E, Guglielmetti S, Fosso B, D'Erchia AM, Maina V, Taverniti V, Castiello MC, Mantero S, Pacchiana G, Musio S, Pedotti R, Selmi C, Mora JR, Pesole G, Vezzoni P, Poliani PL, Grassi F, Villa A, Cassani B. Intestinal microbiota sustain inflammation and autoimmunity induced by hypomorphic RAG defects. J Exp Med. 2016 Mar 7;213(3):355-75. doi: 10.1084/jem.20151116. Epub 2016 Feb 29.
 
3. Abou-Hamdan M, Costanza M, Fontana E, Di Dario M, Musio S, Congiu C, Onnis V, Lattanzi R, Radaelli M, Martinelli V, Salvadori S, Negri l, Poliani PL, Farina C, Balboni G, Steinman L, Pedotti R. Critical role for prokineticin 2 in central nervous system autoimmunity. Neurology, Neuroimmunology and Neuroinflammation. 2015 Apr 9;2(3):e95.
 
4. Costanza M, Binart N, Steinman L, Pedotti R. Prolactin: A versatile regulator of inflammation and autoimmune pathology. Autoimmunity Reviews 2015 Mar;14(3):223-230.
 
5. Menon R, Di Dario M, Cordiglieri C, Musio S, La Mantia L, Milanese C, Di Stefano AL, Crabbio M, Franciotta D, Bergamaschi R, Pedotti R, Medico E, Farina C. Gender-based blood transcriptomes and interactomes in multiple sclerosis: Involvement of SP1 dependent gene transcription. J Autoimmunity. 2012 May;38(2-3):J144-55.
 
6. Costanza M, Musio S, Abou-Hamdan M, Binart N, Pedotti R. Prolactin Is Not Required for the Development of Severe Chronic Experimental Autoimmune Encephalomyelitis. J Immunology. 2013 Sep 1;191(5):2082-8.
 
7. Piconese S, Costanza M, Musio S, Tripodo C, Poliani PL, Gri G, Burocchi A, Pittoni P, Gorzanelli A, Colombo MP and Pedotti R. Exacerbated experimental autoimmune encephalomyelitis in mast cell-deficient KitW-sh/W-sh mice. Laboratory Investigation 2011 Feb 14;91,627–641.
 
8. Piconese S, Gri G, Tripodo C, Musio S, Gorzanelli A, Frossi B, Pedotti R, Pucillo CE, and Colombo MP. Mast cells counteract regulatory T cell suppression through interleukin-6 and OX40/OX40L axis toward Th17 cell differentiation. Blood 2009 Sep 24;114(13):2639-48.
 
9. Scabeni S, Lapilla M, Musio S, Gallo B, Ciusani E, Steinman L, Mantegazza R, and Pedotti R. CD4+CD25+ Tregs specific for a thymus-expressed antigen prevent the development of anaphylaxis to self. J Immunology 2008 Apr 1;180(7):4433-40.
 
10. Gerdoni E., Gallo B, Casazza S, Musio S, Bonanni I, Pedemonte E, Mantegazza R, Mancardi GL, Pedotti R, Uccelli A. Mesenchymal stem cells effectively modulate immune response against PLP139-151 in experimental autoimmune encephalomyelitis. Annals of Neurology 2007 Mar;61(3):219-27.
 
11. Musio S, Gallo B, Scabeni S, Poliani PL, Matarese G, Ohtsu H, Galli SJ, Mantegazza R, Steinman L, Pedotti R. A key regulatory role for histamine in experimental autoimmune encephalomyelitis: Disease exacerbation in histidine decarboxylase-deficient mice. J Immunology. 2006 Jan; 176(1):17-26.
 
12. Robinson WH, Fontoura P, Lee BJ, De Vegvar HE, Tom J, Pedotti R, DiGennaro CD, Mitchell DJ, Fong D, Ho PP, Ruiz PJ, Maverakis E, Stevens DB, Bernard CC, Martin R, Kuchroo VK, Van Noort JM, Genain CP, Amor S, Olsson T, Utz PJ, Garren H, Steinman L.Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis. Nature Biotechnology. 2003 Sep;21(9):1033-1039.
 
13. Pedotti R, DeVoss J, Steinman L, Galli S. Involvement of both 'allergic' and 'autoimmune' mechanisms in EAE, MS and other autoimmune diseases. Trends Immunology. 2003 Sep;24(9):479-84. With journal cover.
 
14. Pedotti R, DeVoss JJ, Youssef S, Mitchell D, Wedemeyer J, Madanat R, Garren H, Fontoura P, Tsai M,  Galli SJ, Sobel RA, Steinman L. Multiple Elements of the Allergic Arm of the Immune Response Modulate Autoimmune Demyelination. Proceedings of the National Academy of Science USA. 2003 Feb 18;100(4):1867-72.
 
15. Karpuj MV, Becher MW, Springer JE, Chabas D, Youssef S, Pedotti R, Mitchell D, Steinman L. Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine. Nature Medicine 2002 Feb;8(2):143-9.
 
16. Lock C*, Hermans G*, Pedotti R*, Brendolan A, Schadt E, Garren H, Langer-Gould A, Strober S, Cannella B, Allard J, Klonowski P, Austin A, Lad N, Kaminski N, Galli SJ, Oksenberg JR, Raine CS, Heller R, Steinman L. Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nature Medicine. 2002 May;8(5):500-8. *Equal contribution
 
17. Chabas D, Baranzini SE, Mitchell D, Bernard CCA, Rittling SR, Denhardt DT, Sobel RA, Lock C, Karpuj M, Pedotti R, Heller R,  Oksenberg JR, and Steinman L. “The influence of the proinflammatory cytokine, osteopontine, on autoimmune demyelinating disease”. Science, 2001 Nov, 294, 1731-5.
 
18. Pedotti R, Mitchell D, Wedemeyer J,  Karpuj M, Chabas, Hattab E, Tsai M, Galli SJ, Steinman L. “An unexpected version of horror autotoxicus: anaphylactic shock to a self-peptide”. Nature Immunology 2001 Mar;2(3):216-22..
 
Last modified on Thursday, 11 May 2017 12:12

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