CATANIA ANNA

Research themes
Antiinflammatory influences of the neuropeptide alpha-MSH 

Keywords
Microglia, phagocytes, NF-kB, inflammation, pro-opiomelanocortin, melanocortin peptides, melanocortin receptors 

Methods
Cell Biology, molecular biology (quantitative PCR, cDNA microarrays, Western blot), animal models

Composition of the research group

• Anna CATANIA MD, Director, Center for Preclinical Investigation, IRCCS Ca' Granda, Ospedale Maggiore Policlinico di Milano


• Stefano GATTI MD, PhD, Director, Center for Surgical Research, IRCCS Ca' Granda, Ospedale Maggiore Policlinico di Milano


• Caterina Lonati, Biologist Center for Preclinical Investigation, IRCCS Ca' Granda, Ospedale Maggiore Policlinico di Milano


• Andrea CARLIN Biologist, Department of Anesthesiology, Università Degli Studi di Milano


• Patrizia LEONARDI Biologist, Department of Anesthesiology, Università Degli Studi di Milano

Recent publications

1. Colombo G, Sordi A, Lonati C, Carlin A, Turcatti F, Leonardi P, Gatti S, Catania A. Treatment with -melanocyte stimulating hormone preserves calcium regulatory proteins in rat heart allografts. Brain Behav Immun 22:817-823, 2008


2. Catania A. Neuroprotective actions of melanocortins: a therapeutic opportunity. Trends Neurosci 31: 354-360, 2008


3. Catania A., Lipton JM. Antimicrobial properties of melanocortins: comment to the manuscript "Anti-Candida activity of α-melanocyte-stimulating hormone α-MSH peptides" by Isabella Rauch et al. J Leukoc Biol 85:373, 2009


4. Todd SR, Kao LS, Catania A, Mercer DW, Adams SD, Moore FA: α-Melanocyte stimulating hormone in critically injured trauma patients. J Trauma 66:465-469, 2009


5. Romagnoli S, Fasoli E, Vaira V, Falleni M, Pellegrini C, Catania A, Roncalli M, Marchetti A, Santambrogio L, Coggi G, Bosari S: Identification of potential therapeutic targets in malignant mesothelioma using cell-cycle gene expression analysis. Am J Pathol 174:762-770, 2009 7


6. Capsoni F, Ongari AM, Reali E, Catania A. Melanocortin peptides inhibit urate crystal-induced activation of phagocytic cells. Arthritis Res Ther 11:R151,1-8, 2009


7. Catania A, Lonati C, Sordi A, Gatti S. Detrimental consequences of brain injury on peripheral cells. Brain Behav Immun 23:877-884, 2009


8. Catania A, Lonati C, Sordi A, Leonardi P, Carlin A, Gatti S. The peptide NDP-MSH induces phenotype changes in the heart that resemble ischemic preconditioning. Peptides 31:116-22, 2010


9. Catania A, Lonati C, Sordi A, Carlin A, Leonardi P, Gatti S. The melanocortin system in control of inflammation. TheScientificWorldJournal 10:1840-1853, 2010


10. Gatti, S., Lonati, C., Sordi, A., and Catania, A.. Protective effects of melanocortins in systemic host reactions. Adv Exp Med Biol 681, 117-125, 2010.


11. Stafstrom, C. E., Arnason, B. G., Baram, T. Z., Catania, A., Cortez, M. A., Glauser, T. A., Pranzatelli, M. R., Riikonen, R., Rogawski, M. A., Shinnar, S., and Swann, J. W.. Treatment of infantile spasms: emerging insights from clinical and basic science perspectives. J Child Neurol 26, 1411-1421, 2011.


12. Gatti, S., Lonati, C., Acerbi, F., Sordi, A., Leonardi, P., Carlin, A., Gaini, S. M., Catania, A. Protective action of NDP-MSH in experimental subarachnoid hemorrhage. Exp Neurol, 234:230-8, 2012.


13. Lonati, C., Sordi, A., Giuliani, D., Spaccapelo, L., Leonardi, P., Carlin, A., Ottani, A., Galantucci, M., Grieco, P., Catania, A., Guarini, S., Molecular Changes Induced in Rat Liver by Hemorrhage and Effects of Melanocortin Treatment. Anesthesiology, 116:692-700, 2012.


14. Arnason BG, Berkovich R, Catania A, Lisak RP, Zaidi M Mechanisms of action of adrenocorticotropic hormone and other melanocortins relevant to the clinical management of patients with multiple sclerosis. Mult Scler, 19:130-6, 2013
    
    Book:
    
    Catania A. (Editor). Melanocortins: Multiple Actions and Therapeutic Potential. Book Series: Advances in Experimental Medicine and Biology. Volume: 681, Springer-Verlag , 2010